It does not matter what the game is. I just find it freaking hilarious whenever somebody says "Oh, you got to kidding me!" because you always know that if they say that line, then you are pretty screwed for the next few minutes.

FunnyFurret : mine would have to be from kid Icarus uprising " FLOOR ICE CREAM GIVES U HEALTH!!!!!!!!!!!!!!!!!!!!!!!!

"You ain't seen what I'm wearing under this wet-suit."

Just go ahead and reminisce everyone who has played Binary Domain.

FunnyFurret : That is seriously too easy! Transformers: Cybertron Adventures. Ironhyde and Bumble Bee have been captured by the Decipticons. The autobots launch an all out assault that knocks out some of the power and allows Ironhyde to escape from his electronic chains. As he is running around smashing the decepticons he says this: "It's a simple concept...You lock us up. We shut you down" I laughed pretty hard on that one. That is one of the best lines that I ever remember hearing in the cours of a game.

One of the quotes that I like from video games has to be from Tales of Symphonia: Dawn of the New World (even though I hated playing the sequel): Courage is the magic that turns dreams into reality.

I blame the game grumps but when they were playing sonic 06 my favorite catch phrase is "ITS NO USE!!" When silver somehow to get in some weird glitch thing where he would repeat it constantly. Matter of fact, I use it in my daily life. When my bro wants to open a new jar of grape jelly. I go "Its no use!!" and we both laugh because its basically true. Its sometimes hard trying to open up one of those jars.
lol

"Faker? I think you're the fake hedgehog around here. Ha! You're not even good enough to be my fa-"
"I'LL MAKE YOU EAT THOSE WORDS!"

Portal: "I'd just like to point out that you were given every opportunity to succeed. There was even going to be a party for you. A big party that all your friends were invited to. I invited your best friend, the Companion Cube. Of course, he couldn't come, because you murdered him. All your other friends couldn't come either, because you don't have any other friends. Because of how unlikeable you are. It says so here in your personnel file: unlikeable. Liked by no one. A bitter, unlikeable loner whose passing shall not be mourned. "Shall not be mourned." That's exactly what it says. Very formal. Very official. It also says you were adopted. So that's funny too."

Probably Zero Wing's "ALL YOUR BASE ARE BELONG TO US" line.

Man there are a lot of quotes you could put in here that would be hilarious but I would have to say my absolute favorite is from red dead redemption - "There are two ways of arguing with a woman, and neither one works." -- John Marston
To me that one just sums it up and is funny as hell. I love it and never get tired of it.

I have plenty of favorite lines from different games, so I guess I'll just name one here.

I'll never forget in Spec Ops: The Line, the main character, Walker, is overlooking a sand-engulfed city of Dubai and he says "Everything is teetering on the edge of everything." I believe its in the middle part of the game when he says this, because a huge sandstorm rolled through the city, completely covering everything in sand.

Its also a pretty cool game to play if you have not yet played it. Its an easy platinum trophy for the PS3, in my opinion.

"We're going to make a bomb!" Curly Brace
"HUZZAH!" Balrog (Or "OH YEAH!")

Just seeing this thread a few sprang to mind first is

No More Heros (As he looks at the player through the fourth wall):
"IT'S GAME TIME!!" - Travis Touchdown


The Next few come from

Tales of Symphonia:
Zelos Wilder: What's your name, beautiful?
Raine Sage: Give me your name, and I'll give you mine.
Genis Sage: Hey, you copied Lloyd!
Lloyd Irving: Now that I've heard someone say it, it sounds kind of arrogant...


[after Colette declines Lloyd's offer to go on a walk]
Genis Sage: [sing-song tease] Ha, ha. You got re-jec-ted.
Lloyd Irving: [p***** off] Hey, shut up, Genis!


[sometimes says this when you win the battle with Lloyd, Colette and Genis in the party]
Genis Sage: Dwarven Vow #7...
Colette Brunel: Justice and love will always win.
Lloyd Irving: Uh, I hate that saying.


Colette Brunel: [Occasionally at the end of a battle, if these three are in the party] Our weapons are love!...
Genis Sage: Justice! And...
Kratos Aurion: [sighs] Hope...


Genis Sage: Presea, I... I... I... I... I...
Presea Combatir: ...
Genis Sage: You're p... p... pretty...
Presea Combatir: P... p... pretty? What is that?
Genis Sage: I... I... I'm complimenting you!
Presea Combatir: ...I see. Then you are p... p... pretty, too.

Don't blame us. Blame yourself. Or God.
Delita from Final Fantasy Tactics

WARNING! MUCH SPOILERS!

My favorite line was recently unearthed again when I replayed a game.

In Jak 3 for the PS2, near the end of the game, the protagonist, Jak, travels to the Core of the planet from a passageway known as the catacombs. He arrives, along with one of the game's antagonists, Count Vegar at a statue of the Precursors, which are supposedly the creators of the universe. After a conversation, a door opens up and reveals the Precursors as small, fuzzy rat like creatures referred to as Ottsels. Jak simply utters:

"Oh my god."

SMBLOZ123 : good cuz i like it yoowza!!

Quote from that overly coloassal, mountain-sized Fell Dragon/Wings of a Despair/Breath of Ruin, (whichever title he's in the mood for, call him that or hell use expiration, which can blow up castles yet can't even hurt a mercenary)
"Arrogant mortal! I am the end!"
I don't know, I just find that freaking awesome, you know?

Hm interesting one - here's a few that I dig:

"I don't know whether I was right or wrong, I guess I'll never know... But I made it. And I guess I should be thankful for that." - STALKER: Shadow of Chernobyl

Until today, I've lived only for myself. Survival has been the only thing I cared about in my life. - Metal Gear Solid